A USP22 inhibitor
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Usp22i-S02

Item No. 42130

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,8,9,10-tetrahydro-11-(phenylamino)-benzimidazo[1,2-b]isoquinoline-6-carbonitrile
CAS Number
309735-96-4
Synonyms
  • Usp22-IN-1
  • Usp22 Inhibitor 1
  • Ubiquitin-specific Protease 22-IN-1
  • Ubiquitin-specific Protease 22 Inhibitor 1
  • Ubiquitin-specific Protease 22i-S02
Molecular Formula
C22H18N4
Formula Weight
338.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
N#CC1=C2CCCCC2=C(N3C1=NC4=C3C=CC=C4)NC5=CC=CC=C5
InChi Code
InChI=1S/C22H18N4/c23-14-18-16-10-4-5-11-17(16)21(24-15-8-2-1-3-9-15)26-20-13-7-6-12-19(20)25-22(18)26/h1-3,6-9,12-13,24H,4-5,10-11H2
InChi Key
MAWNMDSAHSUPFA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Usp22i-S02 is an inhibitor of ubiquitin-specific protease 22 (USP22).1 It increases the levels of ubiquitinated forkhead box protein P3 (Foxp3), a target of Usp22, in primary mouse regulatory T cells (Tregs) when used at concentrations of 10, 15, or 20 µM. In vivo, Usp22i-S02 (20 mg/kg per day for five days) reduces tumor volume and increases intratumoral levels of CD4+CD8+ T cells in an LLC1 murine lung cancer model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Montauti, E., Weinberg, S.E., Chu, P., et al. A deubiquitination module essential for Treg fitness in the tumor microenvironment. Sci. Adv. 8(47), eabo4116 (2022).