An inhibitor of NTPDase 3
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PSB-06126

Item No. 42173

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-amino-9,10-dihydro-4-(1-naphthalenylamino)-9,10-dioxo-2-anthracenesulfonic acid, monosodium salt
CAS Number
1052089-16-3
Molecular Formula
C24H15N2O5S • Na
Formula Weight
466.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/mlPBS (pH 7.2): Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C1C2=C(C(C3=C(NC4=CC=CC5=C4C=CC=C5)C=C(S(=O)([O-])=O)C(N)=C13)=O)C=CC=C2.[Na+]
InChi Code
InChI=1S/C24H16N2O5S.Na/c25-22-19(32(29,30)31)12-18(26-17-11-5-7-13-6-1-2-8-14(13)17)20-21(22)24(28)16-10-4-3-9-15(16)23(20)27;/h1-12,26H,25H2,(H,29,30,31);/q;+1/p-1
InChi Key
BLOBABILSRPNHR-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $87

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    10 mg

    $148

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    25 mg

    $348

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    50 mg

    $609

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    Product Description

    PSB-06126 is an inhibitor of nucleoside triphosphate diphosphorylase 3 (NTPDase 3; IC50 = 1.5 µM for the rat enzyme).1 It is selective for NTPDase 3 over NTPDase 1 and -2 at 1 mM. PSB-06126 also activates large-conductance calcium-activated potassium channels (KCa/BK) in rabbit bladder smooth muscle preparations in an inside/out patch-clamp assay (EC50 = 0.841 µM) and inhibits UTP-induced calcium mobilization in 1321N1 astrocytoma cells expressing the human purinergic P2Y4 receptor (IC50 = 7.72 µM).2,3 It selectively increases extracellular ATP levels in isolated bone marrow-derived mesenchymal stem cells (BM-MSCs) isolated from postmenopausal women over those from young women when used at a concentration of 3 µM.4 PSB-06126 increases matrix mineralization in primary postmenopausal women BM-MSCs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baqi, Y., Weyler, S., Iqbal, J., et al. Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases). Purinergic Signal. 5(1), 91-106 (2009).

    2. Roy, S., Large, R.J., Akande, A.M., et al. Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels. Eur. J. Med. Chem. 75, 426-437 (2014).

    3. Rafehi, M., Malik, E.M., Neumann, A., et al. Development of potent and selective antagonists for the UTP-activated P2Y4 receptor. J. Med. Chem. 60(7), 3020-3038 (2017).

    4. Noronha-Matos, J.B., Pinto-Cardoso, R., Bessa-Andrês, C., et al. Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors. Stem Cell Res. Ther. 14(1), 97 (2023).