A GLP-1R positive allosteric modulator
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6,6-Dimethyl-3-(4-methylbenzoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-amine

Item No. 42175

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2-amino-4,5,6,7-tetrahydro-6,6-dimethylbenzo[b]thien-3-yl)(4-methylphenyl)-methanone
CAS Number
1461715-47-8
Molecular Formula
C18H21NOS
Formula Weight
299.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=C(N)SC2=C1CCC(C)(C2)C)C3=CC=C(C)C=C3
InChi Code
InChI=1S/C18H21NOS/c1-11-4-6-12(7-5-11)16(20)15-13-8-9-18(2,3)10-14(13)21-17(15)19/h4-7H,8-10,19H2,1-3H3
InChi Key
YLLLRGILMRXIMY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    50 mg

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    100 mg

    $396

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    250 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    6,6-Dimethyl-3-(4-methylbenzoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-amine is a glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM).1 It increases GLP-1-induced cAMP production by 268.35% in a reporter assay using HEK293 cells expressing human GLP-1R. 6,6-Dimethyl-3-(4-methylbenzoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-amine (5 µM) induces insulin secretion in glucose-stimulated GLP-1 (7-36)-induced INS-1 832/13 cells. It decreases blood glucose levels in a glucose tolerance test in fasted mice when administered at doses of 10 or 30 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Campbell, J.A., Do, P., Li, Z., et al. Synthesis and biological studies of 2-aminothiophene derivatives as positive allosteric modulators of glucagon-like peptide 1 receptor. Bioorg. Med. Chem. 111, 117864 (2024).