A glycolipid
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6-Trehalose Monooleate

Item No. 42211

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-D-glucopyranosyl-α-D-glucopyranoside, 6-(9Z)-9-octadecenoate
CAS Number
338733-38-3
Synonyms
  • 6-TMO
Molecular Formula
C30H54O12
Formula Weight
606.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble: 0.1-1 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O[C@H]([C@H]1O)[C@H](O[C@@H]([C@H]1O)COC(CCCCCCC/C=C\CCCCCCCC)=O)O[C@@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2
InChi Code
InChI=1S/C30H54O12/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(32)39-19-21-24(34)26(36)28(38)30(41-21)42-29-27(37)25(35)23(33)20(18-31)40-29/h9-10,20-21,23-31,33-38H,2-8,11-19H2,1H3/b10-9-/t20-,21-,23-,24-,25+,26+,27-,28-,29-,30-/m1/s1
InChi Key
MLVMMWOWJSIKLS-WYVBACLFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    6-Trehalose monooleate is a glycolipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of immunosuppressants ex vivo.1 LNPs containing 6-trehalose monooleate and encapsulating cyclosporin A (Item No. 12088) preferentially accumulate in the stratum corneum over the epidermis and dermis in a tape-stripping test using isolated rabbit ear skin. 6-Trehalose monooleate has also been used as an anti-aggregation agent for proteins.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Trombino, S., Russo, R., Mellace, S., et al. Solid lipid nanoparticles made of trehalose monooleate for cyclosporin-A topic release. J. Drug Deliv. Sci. Technol. 49, 563-569 (2019).

    2. Kale, S.S., and Akamanchi, K.G. Trehalose monooleate: A potential antiaggregation agent for stabilization of proteins. Mol. Pharm. 13(12), 4082-4093 (2016).