A DAPK1 and DAPK3 inhibitor
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HS-38

Item No. 42246

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[1-(3-chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-propanamide
CAS Number
1030203-81-6
Molecular Formula
C14H12ClN5O2S
Formula Weight
349.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(N)C(SC1=NC(C2=C(N1)N(N=C2)C3=CC(Cl)=CC=C3)=O)C
InChi Code
InChI=1S/C14H12ClN5O2S/c1-7(11(16)21)23-14-18-12-10(13(22)19-14)6-17-20(12)9-4-2-3-8(15)5-9/h2-7H,1H3,(H2,16,21)(H,18,19,22)
InChi Key
NASYEGAVCTZSDO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $37

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    10 mg

    $65

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    25 mg

    $154

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    50 mg

    $291

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    Product Description

    HS-38 is an inhibitor of death-associated protein kinase 1 (DAPK1; IC50 = 200 nM) and DAPK3.1 It selectively binds to DAPK1, DAPK2, and DAPK3 (Kds = 300, 79, and 280 nM, respectively) over Pim-1, Pim-2, and Pim-3 (Kds = 1,800, 6,500, and 810 nM, respectively) but does inhibit Pim-3 (IC50 = 200 nM). HS-38 (10 µM) inhibits phosphorylation of the DAPK3 target protein regulatory myosin light chain (RLC20) in primary human coronary artery smooth muscle cells. It reduces phenylephrine-induced contractions in isolated mouse aortic rings and increases the time to reach 50% maximal contractions in calyculin A-stimulated isolated rat caudal arterial smooth muscle strips when used at concentrations of 10 and 100 µM, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carlson, D.A., Franke, A.S., Weitzel, D.H., et al. Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. ACS Chem. Biol. 8(12), 2715-2723 (2013).