An ALDH1A3 inhibitor
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KOTX1

Item No. 42249

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-ethyl-N-(7-fluoro-1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)-4-pyridinecarboxamide
CAS Number
1788963-83-6
Molecular Formula
C17H16FN3O2
Formula Weight
313.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
FC1=C(C=C2C(NC(CC2)=O)=C1)NC(C3=C(CC)C=NC=C3)=O
InChi Code
InChI=1S/C17H16FN3O2/c1-2-10-9-19-6-5-12(10)17(23)21-15-7-11-3-4-16(22)20-14(11)8-13(15)18/h5-9H,2-4H2,1H3,(H,20,22)(H,21,23)
InChi Key
QJJWNFKDFKNPEV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $61

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    5 mg

    $273

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    10 mg

    $484

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    KOTX1 is an inhibitor of aldehyde dehydrogenase 1A3 (ALDH1A3; IC50 = 5.14 nM).1 It potentiates glucose-induced insulin secretion from pancreatic islets isolated from patients with type 2 diabetes when used at a concentration of 10 µM. KOTX1 (40 mg/kg per day) decreases plasma insulin levels and reduces blood glucose levels in an intraperitoneal glucose tolerance test (IPGTT) in diabetic db/db male mice. It decreases blood glucose levels and increases plasma insulin levels in a mouse model of obesity induced by a high-fat diet when administered in the diet at 270 ppm.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Son, J., Du, W., Esposito, M., et al. Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure. Nat. Commun. 14(1), 558 (2023).