An NR2B subunit-containing NMDA receptor antagonist
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TCN 237 (hydrochloride)

Item No. 42266

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-[(2-fluorophenyl)methyl]-1-piperidinyl]methyl]-1H-benzimidazol-6-ol, dihydrochloride
CAS Number
1784252-90-9
Molecular Formula
C20H22FN3O • 2HCl
Formula Weight
412.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mL
SMILES
FC1=CC=CC=C1CC2CCN(CC2)CC3=NC4=CC(O)=CC=C4N3.Cl.Cl
InChi Code
InChI=1S/C20H22FN3O.2ClH/c21-17-4-2-1-3-15(17)11-14-7-9-24(10-8-14)13-20-22-18-6-5-16(25)12-19(18)23-20;;/h1-6,12,14,25H,7-11,13H2,(H,22,23);2*1H
InChi Key
JYUWGWCFJMDMND-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $120

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    10 mg

    $208

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    25 mg

    $479

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    Product Description

    TCN 237 is an antagonist of NR2B subunit-containing NMDA receptors (Ki = 0.85 nM).1 It selectively inhibits glutamate and glycine-induced currents in whole-cell patch-clamp assays using L-M(TK-) cells expressing NR2B subunit-containing NMDA receptors over L-M(TK-) cells expressing NR2A- or NR2D subunit-containing NMDA receptors and HEK293 cells expressing NR2C subunit-containing NMDA receptors. TCN 237 (3 mg/kg) inhibits carrageenan-induced mechanical hyperalgesia in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McCauley, J.A., Theberge, C.R., Romano, J.J., et al. NR2B-selective N-methyl-D-aspartate antagonists: Synthesis and evaluation of 5-substituted benzimidazoles. J. Med. Chem. 47, 2089-2096 (2004).