An LTD4 and LTE4 antagonist
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SR 2640

Item No. 42267

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[3-(2-quinolinylmethoxy)phenyl]amino]-benzoic acid
CAS Number
105350-26-3
Molecular Formula
C23H18N2O3
Formula Weight
370.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=C(NC2=CC(OCC3=NC4=C(C=C3)C=CC=C4)=CC=C2)C=CC=C1)O
InChi Code
InChI=1S/C23H18N2O3/c26-23(27)20-9-2-4-11-22(20)24-17-7-5-8-19(14-17)28-15-18-13-12-16-6-1-3-10-21(16)25-18/h1-14,24H,15H2,(H,26,27)
InChi Key
LMPZHLXYBWGGNT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $131

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    10 mg

    $197

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    25 mg

    $393

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    50 mg

    $655

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    Product Description

    SR 2640 is an antagonist of leukotriene D4 (LTD4; Item No. 20310) and LTE4 (Item No. 20410).1 It inhibits LTD4- or LTE4-induced contraction of isolated guinea pig ileum (IC50s = ~0.003 µM for both), but not LTC4-induced contractions. SR 2640 (1 mg/kg) inhibits ovalbumin-induced bronchoconstriction in anesthetized guinea pigs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ahnfelt-Rønne, I., Kirstein, D., and Kaergaard-Nielsen, C. A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur. J. Pharmacol. 155(1-2), 117-128 (1988).