An herbicide
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Tiafenacil

Item No. 42290

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenyl]thio]-1-oxopropyl]-β-alanine, methyl ester
CAS Number
1220411-29-9
Molecular Formula
C19H18ClF4N3O5S
Formula Weight
511.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
O=C(C=C(C(F)(F)F)N(C)C1=O)N1C(C=C2SC(C(NCCC(OC)=O)=O)C)=C(F)C=C2Cl
InChi Code
InChI=1S/C19H18ClF4N3O5S/c1-9(17(30)25-5-4-16(29)32-3)33-13-7-12(11(21)6-10(13)20)27-15(28)8-14(19(22,23)24)26(2)18(27)31/h6-9H,4-5H2,1-3H3,(H,25,30)
InChi Key
QPTPZPIXUPELRM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Tiafenacil is an herbicide.1 It inhibits protoporphyrinogen IX oxidase (PPO; IC50 = 28 nM for the A. thaliana enzyme). Foliar application of tiafenacil (1 µM per day for seven days) induces death in velvetleaf (A. theophrasti), amaranth (A. cruentus), soybean (G. max), and rapeseed (B. napus) seedlings. It induces death in common lambsquarters (C. giganteum), kochia (K. scoparia), redroot pigweed (A. retroflexus), and green foxtail (S. viridis) in pre-plant field studies when applied at a concentration of 49.6 g/ha.2 Tiafenacil is toxic to zebrafish (EC50 = 821.7 µg/L).3 It induces hypoactivity, increases reactive oxygen species (ROS) levels, and decreases heart rate in zebrafish when used at a concentration of 10 µg/L. Formulations containing tiafenacil have been used for weed control in residential and agricultural areas.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, J., Ahn, Y.O., Nam, J.-W., et al. Biochemical and physiological mode of action of tiafenacil, a new protoporphyrinogen IX oxidase-inhibiting herbicide. Pestic. Biochem. Physiol. 152, 38-44 (2018).

    2. Montgomery, C.L.-M., Spackman, J.A., Schroeder, K.L., et al. Efficacy, crop response, and economics of alternatives to glyphosate for pre-plant weed control in small grains. Agrosyst. Geosci. Environ. 7(3), e20551 (2024).

    3. Ivantsova, E., Konig, I., Lopez-Scarim, V., et al. Molecular and behavioral toxicity assessment of tiafenacil, a novel PPO-inhibiting herbicide, in zebrafish embryos/larvae. Environ. Toxicol. Pharmacol. 98:104084, (2023).