A potential impurity in the synthesis of metronidazole
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Parent Compound(s)
9002409Metronidazole
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Metronidazole Impurity G

Item No. 42291

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-5-nitro-1H-imidazole-1-acetic acid
CAS Number
1010-93-1
Synonyms
  • Metronidazole Acetic Acid
  • MNZ Acetic Acid
  • MNZ Impurity G
Molecular Formula
C6H7N3O4
Formula Weight
185.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(CN1C(C)=NC=C1[N+]([O-])=O)O
InChi Code
InChI=1S/C6H7N3O4/c1-4-7-2-5(9(12)13)8(4)3-6(10)11/h2H,3H2,1H3,(H,10,11)
InChi Key
RVEGZXNRNWUYKI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Metronidazole impurity G is a potential impurity found in commercial preparations of metronidazole.1 It is also an inactive metabolite of metronidazole (Item No. 9002409).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matmour, D., Hamoum, N., Hassam, K.F.E., et al. Analysis of seven drug related impurties in six samples of Metronidazole API by high performance liquid chromatography. J. Trace Elem. Miner. 3(8), 100048 (2023).

    2. Pendland, S.L., Piscitelli, S.C., Schreckenberger, P.C., et al. In vitro activities of metronidazole and its hydroxy metabolite against Bacteroides spp. Antimicrob. Agents Chemother. 38(9), 2106-2110 (1994).