A dopamine D4 receptor antagonist
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FAUC-213

Item No. 42322

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-pyrazolo[1,5-a]pyridine
CAS Number
337972-47-1
Molecular Formula
C18H19ClN4
Formula Weight
326.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mLEthanol: Sparingly Soluble: 1-10 mg/mL
SMILES
ClC1=CC=C(N2CCN(CC2)CC3=NN(C=CC=C4)C4=C3)C=C1
InChi Code
InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)14-16-13-18-3-1-2-8-23(18)20-16/h1-8,13H,9-12,14H2
InChi Key
DTRXURJDKOYCCD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 mg

    $50

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    5 mg

    $198

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    10 mg

    $323

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    25 mg

    $620

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    Product Description

    FAUC-213 is a dopamine D4 receptor antagonist (Ki = 2.2 nM).1 It is selective for dopamine D4 receptors over dopamine D2L, D2S, and D3 receptors (Kis = 3,400, 6,300, and 5,300 nM, respectively). FAUC-231 (7.5, 15, and 30 mg/kg) reduces amphetamine-induced hyperactivity in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Löber, S., Hübner, H., Utz, W., et al. Rationally based efficacy tuning of selective dopamine D4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213). J. Med. Chem. 44(17), 2691-2694 (2001).

    2. Boeckler, F., Russig, H., Zhang, W., et al. FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia. Psychopharmacology (Berl) 175(1), 7-17 (2004).