A dopamine D4 receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

FAUC-213

Item No. 42322

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-pyrazolo[1,5-a]pyridine
CAS Number
337972-47-1
Molecular Formula
C18H19ClN4
Formula Weight
326.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mLEthanol: Sparingly Soluble: 1-10 mg/mL
SMILES
ClC1=CC=C(N2CCN(CC2)CC3=NN(C=CC=C4)C4=C3)C=C1
InChi Code
InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)14-16-13-18-3-1-2-8-23(18)20-16/h1-8,13H,9-12,14H2
InChi Key
DTRXURJDKOYCCD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 mg

    $50

    Add

    5 mg

    $198

    Add

    10 mg

    $323

    Add

    25 mg

    $620

    Add
    Product Description

    FAUC-213 is a dopamine D4 receptor antagonist (Ki = 2.2 nM).1 It is selective for dopamine D4 receptors over dopamine D2L, D2S, and D3 receptors (Kis = 3,400, 6,300, and 5,300 nM, respectively). FAUC-231 (7.5, 15, and 30 mg/kg) reduces amphetamine-induced hyperactivity in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Löber, S., Hübner, H., Utz, W., et al. Rationally based efficacy tuning of selective dopamine D4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213). J. Med. Chem. 44(17), 2691-2694 (2001).

    2. Boeckler, F., Russig, H., Zhang, W., et al. FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia. Psychopharmacology (Berl) 175(1), 7-17 (2004).