A Cdk2 inhibitor
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CDK2 Inhibitor 73

Item No. 42335

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(6-[1,1′-biphenyl]-3-yl-9H-purin-2-yl)amino]-benzenesulfonamide
CAS Number
2079895-42-2
Synonyms
  • CDK2-IN-4
  • CDK2-IN-73
  • CDK2 Inhibitor 4
  • Cyclin-Dependent Kinase 2-IN-4
  • Cyclin-Dependent Kinase 2-IN-73
  • Cyclin-Dependent Kinase 2 Inhibitor 4
  • Cyclin-Dependent Kinase 2 Inhibitor 73
Molecular Formula
C23H18N6O2S
Formula Weight
442.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=S(N)(C1=CC=C(NC2=NC(C3=CC=CC(C4=CC=CC=C4)=C3)=C5NC=NC5=N2)C=C1)=O
InChi Code
InChI=1S/C23H18N6O2S/c24-32(30,31)19-11-9-18(10-12-19)27-23-28-20(21-22(29-23)26-14-25-21)17-8-4-7-16(13-17)15-5-2-1-3-6-15/h1-14H,(H2,24,30,31)(H2,25,26,27,28,29)
InChi Key
FUGRWXRQJGJIER-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $64

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    5 mg

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    10 mg

    $447

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    25 mg

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    Product Description

    CDK2 inhibitor 73 is an inhibitor of cyclin-dependent kinase 2 (Cdk2; IC50 = 0.044 µM).1 It is selective for Cdk2 over Cdk1, Cdk4, Cdk7, and Cdk9 at 100 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Coxon, C.R., Anscombe, E., Harnor, S.J., et al. Cyclin-dependent kinase (CDK) inhibitors: Structure-activity relationships and insights into the CDK-2 selectivity of 6-substituted 2-arylaminopurines. J. Med. Chem. 60(5), 1746-1767 (2017).