A nonionic surfactant and emulsifier
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Polysorbate 80

Item No. 42369

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
poly(oxy-1,2-ethanediyl) derivs. mono-(9Z)-9-octadecenoate sorbitan
CAS Number
9005-65-6
Formulation (Request formulation change)
A liquid
Solubility(Learn about Variance in Solubility)
Water: soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 g

    $28

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    100 g

    $42

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    Cayman Chemical
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    Product Description

    Polysorbate 80 is a nonionic surfactant and emulsifier.1,2 It has a critical micelle concentration (CMC) of approximately 13 µM in water at room temperature.2 Polysorbate 80 has been used to solubilize and stabilize proteins and in the formation of cationic nanoparticles, nanostructured lipid carriers (NLCs), and solid lipid nanoparticles (SLNs) and for the delivery of plasmid DNA, siRNA, and small molecules in vitro and in vivo.1,2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nayak, V.S., Tan, Z., Ihnat, P.M., et al. Evaporative light scattering detection based HPLC method for the determination of polysorbate 80 in therapeutic protein formulations. J. Chromatogr. Sci. 50(1), 21-25 (2012).

    2. Hillgren, A., Lindgren, J., and Aldén, M. Protection mechanism of Tween 80 during freeze-thawing of a model protein, LDH. Int. J. Pharm. 237(1-2), 57-69 (2002).

    3. Hattori, Y. Development of non-viral vector for cancer gene therapy. Yakugaku Zasshi 130(7), 917-923 (2010).

    4. Wang, T., Xue, J., Hu, Q., et al. Preparation of lipid nanoparticles with high loading capacity and exceptional gastrointestinal stability for potential oral delivery applications. J. Colloid. Interface Sci. 507, 119-130 (2017).