A β1-adrenergic receptor antagonist
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ICI 89406

Item No. 42370

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-N'-phenyl-urea
CAS Number
53671-71-9
Molecular Formula
C19H22N4O3
Formula Weight
354.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mL
SMILES
N#CC(C=CC=C1)=C1OCC(O)CNCCNC(NC2=CC=CC=C2)=O
InChi Code
InChI=1S/C19H22N4O3/c20-12-15-6-4-5-9-18(15)26-14-17(24)13-21-10-11-22-19(25)23-16-7-2-1-3-8-16/h1-9,17,21,24H,10-11,13-14H2,(H2,22,23,25)
InChi Key
HTLWRKRZKFAAAH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $97

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    25 mg

    $229

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    50 mg

    $432

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    Product Description

    ICI 89406 is an antagonist of ß1-adrenergic receptors (IC50 = 4.2 nM).1 It is selective for ß1-adrenergic receptors over ß2-adrenergic receptors (IC50 = 678 nM). ICI 89406 also acts as a partial agonist at ß1- and ß2-adrenergic receptors, inducing cAMP accumulation in CHO-K1 cells expressing the human receptors (EC50s = 0.81 and 60.26 nM, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nanoff, C., Freissmuth, M., and Schütz, W. The role of a low β1-adrenoceptor selectivity of [3H]CGP-12177 for resolving subtype-selectivity of competitive ligands. Naunyn Schmiedebergs Arch. Pharmacol. 336(5), 519-525 (1987).

    2. Mistry, S.N., Baker, J.G., Fischer, P.M., et al. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists. J. Med. Chem. 56(10), 3852-3865 (2013).