An adenosine A1 receptor positive allosteric modulator
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PD 81723

Item No. 42371

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2-amino-4,5-dimethyl-3-thienyl)[3-(trifluoromethyl)phenyl]-methanone
CAS Number
132861-87-1
Synonyms
  • LY202472
Molecular Formula
C14H12F3NOS
Formula Weight
299.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
O=C(C1=C(N)SC(C)=C1C)C2=CC=CC(C(F)(F)F)=C2
InChi Code
InChI=1S/C14H12F3NOS/c1-7-8(2)20-13(18)11(7)12(19)9-4-3-5-10(6-9)14(15,16)17/h3-6H,18H2,1-2H3
InChi Key
KKDKAWKYGCUOGR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $98

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    10 mg

    $157

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    25 mg

    $368

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    Product Description

    PD 81723 is a positive allosteric modulator of the adenosine A1 receptor.1 PD 81723 (10 µM) inhibits apoptosis induced by TNF-a and cycloheximide (Item No. 14126) in HK-2 kidney epithelial cells.2 It increases right atrial heart rate in combination with adenosine deaminase (ADA) in isolated rat right atria (EC50 = 0.83 nM).3 PD 81723 (3 mg/kg) reduces plasma creatinine levels and infarct area in a mouse model of renal ischemia-reperfusion injury.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bruns, R.F., and Fergus, J.H. Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes. Mol. Pharmacol. 38(6), 939-949 (1990).

    2. Park, S.W., Kim, J.Y., Ham, A., et al. A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury. Am. J. Physiol. Renal. Physiol. 303(5), F721-F732 (2012).

    3. Mudumbi, R.V., Montamat, S.C., Bruns, R.F., et al. Cardiac functional responses to adenosine by PD 81,723, an allosteric enhancer of the adenosine A1 receptor. Am. J. Physiol. 264(3 Pt 2), H1017-H1022 (1993).