A DAPK1 and DAPK3 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

TC-DAPK6

Item No. 42378

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-phenylethenyl)-4-(3-pyridinylmethylene)-5(4H)-oxazolone
CAS Number
315694-89-4
Molecular Formula
C17H12N2O2
Formula Weight
276.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1OC(C=CC2=CC=CC=C2)=NC1=CC3=CN=CC=C3
InChi Code
InChI=1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H
InChi Key
GFGMISOSPOPSHN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $32

    Add

    10 mg

    $61

    Add

    25 mg

    $128

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    TC-DAPK6 is an inhibitor of death-associated protein kinase 1 (DAPK1) and DAPK3 (IC50s = 69 and 225 nM, respectively).1 It is selective for DAPK1 and DAPK3 over 47 other kinases at 10 µM. Hollow mesoporous silica nanocarriers (HMSNs) encapsulating TC-DAPK6 increase the latency to fall and distance traveled on the rod in the rotarod test and decrease the time spent in the center in the open field test in a mouse model of kainic acid-induced epilepsy.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Okamoto, M., Takayama, K., Shimizu, T., et al. Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J. Med. Chem. 52(22), 7323-7327 (2009).

    2. Geng, C., Ren, X., Cao, P., et al. Macrophage membrane‒biomimetic nanoparticles target inflammatory microenvironment for epilepsy treatment. Theranostics 14(17), 6652-6670 (2024).