An NCX1 inhibitor
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SN-6

Item No. 42390

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid, ethyl ester
CAS Number
415697-08-4
Molecular Formula
C20H22N2O5S
Formula Weight
402.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(OCC)C(N1)CSC1CC(C=C2)=CC=C2OCC(C=C3)=CC=C3[N+]([O-])=O
InChi Code
InChI=1S/C20H22N2O5S/c1-2-26-20(23)18-13-28-19(21-18)11-14-5-9-17(10-6-14)27-12-15-3-7-16(8-4-15)22(24)25/h3-10,18-19,21H,2,11-13H2,1H3
InChi Key
ZVYIJXLMBWCGHP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $88

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    10 mg

    $168

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    25 mg

    $352

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    Product Description

    SN-6 is an inhibitor of sodium-calcium exchanger 1 (NCX1; IC50 = 2.9 µM).1 It is selective for NCX1 over NCX2, NCX3, and sodium-potassium-calcium exchanger 2 (NCKX2; IC50s = 16, 8.6, and >30 µM, respectively) and a panel of 26 additional ion channels and receptors at 30 µM. SN-6 inhibits bidirectional inward and outward currents and unidirectional outward currents in whole-cell voltage-clamp assays using isolated guinea pig ventricular myocytes (IC50s = 1.9, 2.3, and 0.6 µM, respectively).2 It reduces hypoxia-reoxygenation-induced lactate dehydrogenase (LDH) release in LLC-PK1 porcine kidney epithelial cells overexpressing NCX1 (IC50 = 0.63 µM).1 In vivo, SN-6 (10 mg/kg) decreases ethanol intake and preference in female rats.3 It decreases the incidence of clonic and tonic-clonic seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in rats when administered at doses ranging from 1 to 30 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iwamoto, T., Inoue, Y., Ito, K., et al. The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol. Pharmacol. 66(1), 45-55 (2004).

    2. Niu, C.-F., Watanabe, Y., Ono, K., et al. Characterization of SN-6, a novel Na+/Ca2+ exchange inhibitor in guinea pig cardiac ventricular myocytes. Eur. J. Pharmacol. 573(1-3), 161-169 (2007).

    3. Silva-Cardoso, G.K., and N'Gouemo, P. Inhibition of the sodium-calcium exchanger reverse mode activity reduces alcohol consumption in rats. Int. J. Mol. Sci. 25(7), 4132 (2025).

    4. N'Gouemo, P. Probing the role of the sodium/calcium exchanger in pentylenetetrazole-induced generalized seizures in rats. Brain Res. Bull. 90, 52-57 (2013).