An antagonist of the androgen receptor NTD
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Isomer(s)
16970EPI-001
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Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

Cancer

Ralaniten

Item No. 42391

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-3-[4-[1-[4-[(2S)-3-chloro-2-hydroxypropoxy]phenyl]-1-methylethyl]phenoxy]-1,2-propanediol
CAS Number
1203490-23-6
Synonyms
  • EPI-002
Molecular Formula
C21H27ClO5
Formula Weight
394.9
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mLEthanol: Sparingly Soluble: 1-10 mg/mL
SMILES
O[C@@H](COC1=CC=C(C(C)(C)C2=CC=C(OC[C@@H](CCl)O)C=C2)C=C1)CO
InChi Code
InChI=1S/C21H27ClO5/c1-21(2,15-3-7-19(8-4-15)26-13-17(24)11-22)16-5-9-20(10-6-16)27-14-18(25)12-23/h3-10,17-18,23-25H,11-14H2,1-2H3/t17-,18-/m1/s1
InChi Key
HDTYUHNZRYZEEB-QZTJIDSGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $105

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    10 mg

    $158

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    25 mg

    $340

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    50 mg

    $523

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    Cayman Chemical
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    Product Description

    Ralaniten is an antagonist of the androgen receptor N-terminal domain (NTD).1 It inhibits androgen receptor NTD transactivation in a reporter assay (IC50 = 7.4 µM). Ralaniten (10-30 µM) reduces androgen-dependent growth of LNCaP prostate cancer cells. In vivo, ralaniten (50 mg/kg) decreases tumor volume in an LNCaP castration-resistant prostate cancer (CRPC) mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Myung, J.K., Banuelos, C.A., Fernandez, J.G., et al. An androgen receptor N-terminal domain antagonist for treating prostate cancer. J. Clin. Invest. 123(7), 2948-2960 (2013).