A DP2/CRTH2 and DP1 dual antagonist
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AMG 009

Item No. 42392

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-[(butylamino)carbonyl]-2-[[(2,4- dichlorophenyl)sulfonyl]amino]phenoxy]- 3-methoxy-benzeneacetic acid
CAS Number
1027847-67-1
Molecular Formula
C26H26Cl2N2O7S
Formula Weight
581.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(CC1=CC=C(C(OC)=C1)OC(C(NS(C2=CC=C(Cl)C=C2Cl)(=O)=O)=C3)=CC=C3C(NCCCC)=O)O
InChi Code
InChI=1S/C26H26Cl2N2O7S/c1-3-4-11-29-26(33)17-6-9-21(37-22-8-5-16(13-25(31)32)12-23(22)36-2)20(14-17)30-38(34,35)24-10-7-18(27)15-19(24)28/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32)
InChi Key
DKSKRBVXRDGYAS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $83

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    10 mg

    $158

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    50 mg

    $455

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    100 mg

    $743

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    Product Description

    AMG 009 is a dual antagonist of DP2/CRTH2 and DP1 (IC50s = 3 and 12 nM, respectively).1 It decreases airway resistance in a guinea pig model of airflow obstruction induced by aerosolized prostaglandin D2 (PGD2; Item No. 12010) when administered at doses of 3, 10, and 30 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, J., Fu, Z., Wang, Y., et al. Discovery and optimization of CRTH2 and DP dual antagonists. Bioorg. Med. Chem. Lett. 19(22), 6419-6423 (2009).