A DP2/CRTH2 and DP1 dual antagonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AMG 009

Item No. 42392

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-[(butylamino)carbonyl]-2-[[(2,4- dichlorophenyl)sulfonyl]amino]phenoxy]- 3-methoxy-benzeneacetic acid
CAS Number
1027847-67-1
Molecular Formula
C26H26Cl2N2O7S
Formula Weight
581.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(CC1=CC=C(C(OC)=C1)OC(C(NS(C2=CC=C(Cl)C=C2Cl)(=O)=O)=C3)=CC=C3C(NCCCC)=O)O
InChi Code
InChI=1S/C26H26Cl2N2O7S/c1-3-4-11-29-26(33)17-6-9-21(37-22-8-5-16(13-25(31)32)12-23(22)36-2)20(14-17)30-38(34,35)24-10-7-18(27)15-19(24)28/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32)
InChi Key
DKSKRBVXRDGYAS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $83

    Add

    10 mg

    $158

    Add

    50 mg

    $455

    Add

    100 mg

    $743

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    AMG 009 is a dual antagonist of DP2/CRTH2 and DP1 (IC50s = 3 and 12 nM, respectively).1 It decreases airway resistance in a guinea pig model of airflow obstruction induced by aerosolized prostaglandin D2 (PGD2; Item No. 12010) when administered at doses of 3, 10, and 30 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, J., Fu, Z., Wang, Y., et al. Discovery and optimization of CRTH2 and DP dual antagonists. Bioorg. Med. Chem. Lett. 19(22), 6419-6423 (2009).