A peptide antagonist of APJ
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MM-54 (trifluoroacetate salt)

Item No. 42401

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-cysteinyl-L-lysyl-L-histidyl-L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-cysteine, cyclic (1→6),(9→14)-bis(disulfide), trifluoroacetate salt
Molecular Formula
C70H121N29O15S4 • XCF3COOH
Formula Weight
1737.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
cyclic[CRPRLC]-KH-cyclic[CRPRLC]-OH
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly Soluble: 1-10 mg/ml
SMILES
O=C1N2[C@@](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H]1CCCNC(N)=N)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@H]3NC([C@@H](NC([C@@H](NC([C@@]4([H])N(CCC4)C([C@@H](NC([C@H](CSSC3)N)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)=O)=O)CC5=CN=CN5)=O)C(O)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)([H])CCC2.FC(F)(F)C(O)=O
InChi Code
InChI=1S/C70H121N29O15S4.C2HF3O2/c1-36(2)27-45-57(104)95-48(32-116-115-31-39(72)53(100)90-43(16-9-23-84-69(77)78)64(111)98-25-11-18-51(98)62(109)88-41(55(102)92-45)14-7-21-82-67(73)74)60(107)87-40(13-5-6-20-71)54(101)94-47(29-38-30-81-35-86-38)59(106)96-49-33-117-118-34-50(66(113)114)97-58(105)46(28-37(3)4)93-56(103)42(15-8-22-83-68(75)76)89-63(110)52-19-12-26-99(52)65(112)44(91-61(49)108)17-10-24-85-70(79)80;3-2(4,5)1(6)7/h30,35-37,39-52H,5-29,31-34,71-72H2,1-4H3,(H,81,86)(H,87,107)(H,88,109)(H,89,110)(H,90,100)(H,91,108)(H,92,102)(H,93,103)(H,94,101)(H,95,104)(H,96,106)(H,97,105)(H,113,114)(H4,73,74,82)(H4,75,76,83)(H4,77,78,84)(H4,79,80,85);(H,6,7)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-;/m0./s1
InChi Key
KTMDLQYXMOBVMO-QRIILVICSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $87

    Add

    5 mg

    $326

    Add

    10 mg

    $522

    Add

    25 mg

    $978

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    MM-54 is a peptide antagonist of the apelin receptor (APJ; Ki = 82 nM).1 It inhibits apelin-13-induced increases in number of stem cells and tumorspheres and the percentage of cells with aldehyde dehydrogenase (ALDH) activity, a marker of stem cells, in patient-derived glioblastoma spheroids when used at a concentration of 100 µM.2 MM-54 (2 mg/kg twice per week) decreases tumor volume in a patient-derived xenograft (PDX) mouse model of glioblastoma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Macaluso, N.J., Pitkin, S.L., Maguire, J.J., et al. Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem 6(6), 1017-1023 (2011).

    2. Harford-Wright, E., Andre-Gregoire, G., Jacobs, K.A., et al. Pharmacological targeting of apelin impairs glioblastoma growth. Brain 40(11), 2939-2954 (2017).