A conotoxin and an inhibitor of Nav1.4
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

μ-Conotoxin (acetate)

Item No. 42455

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-oxo-L-prolylglycyl-L-cysteinyl-L-cysteinyl-L-asparaginylglycyl-L-prolyl-L-lysylglycyl-L-cysteinyl-L-seryl-L-seryl-L-lysyl-L-tryptophyl-L-cysteinyl-L-arginyl-L-a-aspartyl-L-histidyl-L-alanyl-L-arginyl-L-cysteinyl-L-cysteinamide, cyclic (3?15),(4?21),(10?22)-tris(disulfide), acetate
Synonyms
  • μ-CnIIIC
Molecular Formula
C92H139N35O28S6 • XC2H4O2
Formula Weight
2375.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
[H]N([C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(NCC(N1CCC[C@H]1C(N[C@@H](CCCCN)C(NCC(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@H](C2=O)CC3=CNC4=C3C=CC=C4)=O)=O)=O)=O)CSSC[C@H](N5)C(N)=O)=O)=O)=O)=O)=O)=O)CSSC[C@H](N6)C5=O)=O)CSSC[C@H](N2)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C6=O)=O)C)=O)CC7=CN=CN7)=O)CC(O)=O)=O)=O)=O)=O)CC8)C8=O.CC(O)=O
InChi Code
InChI=1S/C92H139N35O28S6.C2H4O2/c1-43-73(138)113-50(15-8-22-102-91(97)98)79(144)124-64-41-161-160-40-63-88(153)119-55(27-66(95)130)76(141)107-33-70(134)127-24-10-17-65(127)90(155)116-48(13-4-6-20-93)74(139)105-31-68(132)111-60(37-157-156-36-59(72(96)137)123-89(64)154)85(150)122-58(35-129)84(149)121-57(34-128)83(148)114-49(14-5-7-21-94)77(142)117-53(25-44-29-104-47-12-3-2-11-46(44)47)81(146)125-62(39-159-158-38-61(86(151)126-63)112-69(133)32-106-75(140)52-18-19-67(131)110-52)87(152)115-51(16-9-23-103-92(99)100)78(143)120-56(28-71(135)136)82(147)118-54(80(145)109-43)26-45-30-101-42-108-45;1-2(3)4/h2-3,11-12,29-30,42-43,48-65,104,128-129H,4-10,13-28,31-41,93-94H2,1H3,(H2,95,130)(H2,96,137)(H,101,108)(H,105,139)(H,106,140)(H,107,141)(H,109,145)(H,110,131)(H,111,132)(H,112,133)(H,113,138)(H,114,148)(H,115,152)(H,116,155)(H,117,142)(H,118,147)(H,119,153)(H,120,143)(H,121,149)(H,122,150)(H,123,154)(H,124,144)(H,125,146)(H,126,151)(H,135,136)(H4,97,98,102)(H4,99,100,103);1H3,(H,3,4)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-;/m0./s1
InChi Key
FQXXEZBBTACUFG-HJSVBHBKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $39

    Add

    5 mg

    $174

    Add

    10 mg

    $308

    Add

    25 mg

    $675

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    µ-Conotoxin is a conotoxin that has been found in singed cone (C. consors) and is an inhibitor of voltage-gated sodium channel 1.4 (Nav1.4).1 It inhibits Nav1.4 in HEK293 cells (IC50 = 2.3 nM for the rat channel). µ-Conotoxin also inhibits rat Nav1.2 channels in HEK293 cells when used at a concentration of 500 nM and is an antagonist of a7 nicotinic acetylcholine receptors (nAChRs) and a4ß2 and a3ß2 subunit-containing nAChRs in Xenopus oocytes expressing the human receptors (IC50s = 22, 2.9, and 0.45 µM, respectively). It reduces global nerve action potential in isolated mouse sciatic nerves in a concentration-dependent manner. µ-Conotoxin inhibits contraction in isolated mouse hemidiaphragm muscles (IC50 = 46 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Favreau, P., Benoit, E., Hocking, H.G., et al. A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. Br. J. Pharmacol. 166(5), 1654-1668 (2012).