A flavonoid glucoside with diverse biological activities
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Oroxin B

Item No. 42489

Product Insert (PDF)
Technical Information
Formal Name
7-[(6-O-ß-D-glucopyranosyl-ß-D-glucopyranosyl)oxy]-5,6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one
CAS Number
114482-86-9
Synonyms
  • Baicalin-7-O-diglucoside
Molecular Formula
C27H30O15
Formula Weight
594.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
OC1=C2C(OC(C3=CC=CC=C3)=CC2=O)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)=C1O
InChi Code
InChI=1S/C27H30O15/c28-8-15-19(31)22(34)24(36)26(41-15)38-9-16-20(32)23(35)25(37)27(42-16)40-14-7-13-17(21(33)18(14)30)11(29)6-12(39-13)10-4-2-1-3-5-10/h1-7,15-16,19-20,22-28,30-37H,8-9H2/t15-,16-,19-,20-,22+,23+,24-,25-,26-,27-/m1/s1
InChi Key
HAYLVXFWJCKKDW-IJTBWITGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

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    25 mg

    $244

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    50 mg

    $459

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Oroxin B is a flavonoid glucoside that has been found in O. indicum that has diverse biological activities.1,2,3,4 It scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 139.62 µg/ml).1 Oroxin B (20 µM) inhibits the proliferation of Raji lymphoblasts but not isolated human peripheral blood mononuclear cells (PBMCs).2 It induces apoptosis, decreases levels of COX-2, VEGF, PI3K, and phosphorylated Akt, and increases levels of phosphatase and tensin homolog (PTEN) in SMMC-7721 hepatocellular cancer cells when used at a concentration of 1.63 µM.3 Oroxin B (30 mg/kg per day) reduces tumor weight and volume and increases survival in a Raji mouse xenograft model.2 It decreases plasma levels of triglycerides, total cholesterol, LDL, alanine transaminase (ALT), aspartate aminotransferase (AST), TNF-a, and IL-6 and reduces liver levels of TNF-a and IL-6 in rats fed a high-fat diet when administered at a dose of 200 mg/kg per day.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yan, R.Y., Cao, Y.Y., Chen, C.Y., et al. Antioxidant flavonoids from the seed of Oroxylum indicum. Fitoterapia 82(6), 841-848 (2011).

    2. Yang, P., Fu, S., Cao, Z., et al. Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy. Toxicol. Appl. Pharmacol. 288(2), 269-279 (2015).

    3. Li, N.-N., Meng, X.-S., Bao, Y.-R., et al. Evidence for the involvement of COX-2/VEGF and PTEN/Pl3K/AKT pathway the mechanism of Oroxin B treated liver cancer. Pharmacogn. Mag. 14(54), 207-213 (2018).

    4. Huang, Y., Wang, C., Wang, M., et al. Oroxin B improves metabolic-associated fatty liver disease by alleviating gut microbiota dysbiosis in a high-fat diet-induced rat model. Eur. J. Pharmacol. 951 (2023).