A CGRP receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MK-3207

Item No. 42490

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8R-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide
CAS Number
957118-49-9
Molecular Formula
C31H29F2N5O3
Formula Weight
557.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C1[C@]2(CC3=CC(NC(CN4[C@H](C5=CC(F)=CC(F)=C5)CNC6(CCCC6)C4=O)=O)=CC=C3C2)C7=CC=CN=C7N1
InChi Code
InChI=1S/C31H29F2N5O3/c32-21-10-19(11-22(33)13-21)25-16-35-31(7-1-2-8-31)29(41)38(25)17-26(39)36-23-6-5-18-14-30(15-20(18)12-23)24-4-3-9-34-27(24)37-28(30)40/h3-6,9-13,25,35H,1-2,7-8,14-17H2,(H,36,39)(H,34,37,40)/t25-,30+/m0/s1
InChi Key
AZAANWYREOQRFB-SETSBSEESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $47

    Add

    5 mg

    $208

    Add

    10 mg

    $347

    Add
    Product Description

    MK-3207 is an antagonist of the calcitonin gene-related peptide (CGRP) receptor (Ki = 22 pM for the recombinant human receptor).1 It is selective for the CGRP receptor over adrenomedullin receptor 1 (AM1) and AM2, calcitonin (CT) receptor, and amylin 3 receptor (AMY3; Kis = 16.5, 0.156, 1.9, and 0.128 µM, respectively) but does inhibit AMY1 to a lesser extent (Ki = 750 pM). MK-3207 inhibits CGRP-induced cAMP production in HEK293 cells expressing the human CGRP receptor (IC50 = 120 pM). It decreases capsaicin-induced forearm dermal vasodilation in rhesus monkeys in a dose-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Salvatore, C.A., Moore, E.L., Calamari, A., et al. Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J. Pharmacol. Exp. Ther. 333(1), 152-160 (2010).