A SIRT1 activator
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Alternative(s)
10011020SRT 1720 (hydrochloride)
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SRT 1720

Item No. 42531

Product Insert (PDF)
Technical Information
Formal Name
N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
CAS Number
925434-55-5
Synonyms
  • CAY10559
  • SIRT 1933
Molecular Formula
C25H23N7OS
Formula Weight
469.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=NC2=CC=CC=C2N=C1)NC3=C(C4=CN5C(CN6CCNCC6)=CSC5=N4)C=CC=C3
InChi Code
InChI=1S/C25H23N7OS/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31/h1-8,13,15-16,26H,9-12,14H2,(H,29,33)
InChi Key
IASPBORHOMBZMY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $58

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    10 mg

    $87

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    25 mg

    $174

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    50 mg

    $319

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    SRT 1720 is a sirtuin 1 (SIRT1) activator (EC1.5 = 0.16 µM in a cell-free fluorescence polarization assay).1 It reduces acetylated p53 levels in U2OS cells when used at a concentration of 0.1 µM. Oral administration of SRT 1720 (100 mg/kg) reduces fed blood glucose levels, improves insulin sensitivity, and increases mitochondrial capacity in a diet-induced obese (DIO) mouse model of diabetes. It also improves liver, adipose tissue, and skeletal muscle insulin sensitivity in Zucker fa/fa genetically obese rats. SRT 1720 (25 mg/kg) decreases synovitis and delays the progression of surgically induced osteoarthritis in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Milne, J.C., Lambert, P.D., Schenk, S., et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450(7170), 712-716 (2007).

    2. Nishida, K., Matsushita, T., Takayama, K., et al. Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice. Bone Joint Res. 7(3), 252-262 (2018).