An antibiotic potentiator
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Polymyxin B Nonapeptide (trifluoroacetate salt)

Item No. 42533

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-10-polymyxin B1, trifluoroacetate salt
CAS Number
3041171-24-5
Synonyms
  • PBNP
  • PMBN
Molecular Formula
C43H74N14O11 • XCF3COOH
Formula Weight
963.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(NCC[C@@H](C(N[C@H](C(N1)=O)CCN)=O)NC([C@@H](NC([C@H]([C@H](O)C)N)=O)CCN)=O)=O)([H])[C@H](O)C)=O)CCN)=O)CCN)=O)CC(C)C)[C@H]1CC2=CC=CC=C2.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C43H74N14O11.C2HF3O2/c1-22(2)20-31-40(65)52-26(10-15-44)35(60)51-29(13-18-47)39(64)57-34(24(4)59)43(68)49-19-14-30(53-36(61)28(12-17-46)54-42(67)33(48)23(3)58)38(63)50-27(11-16-45)37(62)56-32(41(66)55-31)21-25-8-6-5-7-9-25;3-2(4,5)1(6)7/h5-9,22-24,26-34,58-59H,10-21,44-48H2,1-4H3,(H,49,68)(H,50,63)(H,51,60)(H,52,65)(H,53,61)(H,54,67)(H,55,66)(H,56,62)(H,57,64);(H,6,7)/t23-,24-,26+,27+,28+,29+,30+,31+,32-,33+,34+;/m1./s1
InChi Key
LWUQWBIOVNNTQF-OBIXLILOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Polymyxin B nonapeptide is an antibiotic potentiator and a polymyxin B (Item No. 14157) derivative lacking the acyl chain.1 It increases the sensitivity of E. coli to various antibiotics, including erythromycin (Item No. 16486), rifampicin (Item No. 14423), fusidic acid (Item No. 14825), novobiocin (Item No. 18457), and cloxacillin (Item No. 22249). Polymyxin B nonapeptide (8 µg/ml), in combination with linezolid (Item No. 15012), increases survival in a C. elegans model of K. pneumoniae infection.2 It has been used to increase electroporation-based transformation frequency.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vaara, M., and Vaara, T. Sensitization of Gram-negative bacteria to antibiotics and complement by a nontoxic oligopeptide. Comparative Study 303(5917), 526-528 (1983).

    2. Huang, T., Lv, Z., Lin, J., et al. A potent antibiotic combination of linezolid and polymycin B nonapeptide against Klebsiella pneumoniae infection in vitro and in vivo. Front. Pharmacol. 13, 887941 (2022).

    3. Qin, J., Hong, Y., Pullela, K., et al. A method for increasing electroporation competence of Gram-negative clinical isolates by polymyxin B nonapeptide. Sci. Rep. 12(1), 11629 (2022).