An inhibitor of mutant EGFR
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Rezivertinib

Item No. 42537

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[2-(dimethylamino)ethoxy]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
CAS Number
1835667-12-3
Synonyms
  • BPI-7711
Molecular Formula
C27H30N6O3
Formula Weight
486.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Sparingly soluble: 1-10 mg/mLDMSO: Sparingly soluble: 1-10 mg/mL
SMILES
COC(C=C1OCCN(C)C)=C(C=C1NC(C=C)=O)NC2=NC=CC(C3=CN(C)C4=CC=CC=C43)=N2
InChi Code
InChI=1S/C27H30N6O3/c1-6-26(34)29-22-15-21(24(35-5)16-25(22)36-14-13-32(2)3)31-27-28-12-11-20(30-27)19-17-33(4)23-10-8-7-9-18(19)23/h6-12,15-17H,1,13-14H2,2-5H3,(H,29,34)(H,28,30,31)
InChi Key
BPMZUKYFIDPLEA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $43

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    5 mg

    $151

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    10 mg

    $258

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    25 mg

    $537

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    Product Description

    Rezivertinib is an inhibitor of mutant EGFR.1 It selectively inhibits the proliferation of mutant-EGFR-containing PC-9, HCC827, and H1975 cells (GI50s = 13.3, 6.8, and 22 nM, respectively) over wild-type EGFR-containing A431 cells (GI50 = >1,000 nM). Rezivertinib increases survival in an H1975 brain orthotopic rat model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nagasaka, M., Zhu, V.W., Lim, S.M., et al. Beyond osimertinib: The development of third-generation EGFR tyrosine kinase inhibitors for advanced EGFR+ NSCLC. J. Thorac. Oncol. 16(5), 740-763 (2021).