An aromatic amine antioxidant
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Environmental Toxicology
Toxic Agents
Carcinogens

Research Area

Cancer

N-Phenyl-2-naphthylamine

Item No. 42580

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-phenyl-2-naphthalenamine
CAS Number
135-88-6
Synonyms
  • Aceto PBN
  • 2-Anilinonaphthalene
  • Antioxidant 116
  • Antioxidant D
  • Antioxidant PBN
  • 2-Naphthylphenylamine
  • β-Naphthylphenylamine
  • NSC 37151
  • P2NA
  • PBNA
  • PNA
Molecular Formula
C16H13N
Formula Weight
219.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
C1(NC2=CC3=C(C=CC=C3)C=C2)=CC=CC=C1
InChi Code
InChI=1S/C16H13N/c1-2-8-15(9-3-1)17-16-11-10-13-6-4-5-7-14(13)12-16/h1-12,17H
InChi Key
KEQFTVQCIQJIQW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    N-Phenyl-2-naphthylamine (P2NA) is an aromatic amine antioxidant.1,2 It is non-carcinogenic, however, it can be dephenylated in vivo to 2-naphthylamine (2NA), a carcinogen associated with bladder cancer. P2NA was previously used as a common additive in rubber.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Weiss, T., Bolt, H.M., Schlüter, G., et al. Metabolic dephenylation of the rubber antioxidant N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine in rats. Arch. Toxicol. 87(7), 1265-1272 (2013).

    2. Marek, E.M., Koslitz, S., Weiss, T., et al. Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions. Arch. Toxicol. 91(11), 3587-3596 (2017).