An anti-NASH agent
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Anti-NASH Agent 1

Item No. 42614

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2,6-dimethyl-4-[3-[4-(methylamino)phenyl]-3-oxo-1-propen-1-yl]phenoxy]-2-methyl-propanoic acid, 1,1-dimethylethyl ester
CAS Number
2409685-41-0
Synonyms
  • Anti-Non-Alcoholic Steatohepatitis Agent 1
Molecular Formula
C26H33NO4
Formula Weight
423.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly Soluble: 0.1-1 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
CNC1=CC=C(C(C=CC2=CC(C)=C(C(C)=C2)OC(C)(C(OC(C)(C)C)=O)C)=O)C=C1
InChi Code
InChI=1S/C26H33NO4/c1-17-15-19(9-14-22(28)20-10-12-21(27-8)13-11-20)16-18(2)23(17)30-26(6,7)24(29)31-25(3,4)5/h9-16,27H,1-8H3
InChi Key
JMNQFYWMYKSSSA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $87

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    10 mg

    $165

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    25 mg

    $392

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    50 mg

    $696

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Anti-NASH agent 1 is an anti-non-alcoholic steatohepatitis (NASH) agent and a derivative of the PPARα and PPARδ agonist GFT505 (elafibranor; Item No. 23508).1 It inhibits free fatty acid-induced triglyceride accumulation and aspartate aminotransferase (AST) activity in HepG2 cells when used at a concentration of 40 µM. Anti-NASH agent 1 (3-30 mg/kg) decreases disease severity, reduces serum triglyceride, total cholesterol, LDL, Ast, alanine transaminase (Alt), TNF-α, IL-6, and IL-8 levels, and increases serum HDL and liver glutathione (GSH) levels in a mouse model of NASH induced by a methionine- and choline-deficient diet.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xiang, C., Chen, X., Yao, J., et al. Design, synthesis and anti-NASH effect evaluation of novel GFT505 derivatives in vitro and in vivo. 257, 115510 (2023).