An inhibitor of CDKs
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NVP-LCQ195

Item No. 42728

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(2,6-dichlorobenzoyl)amino]-N-[1-(methylsulfonyl)-4-piperidinyl]-1H-pyrazole-3-carboxamide
CAS Number
902156-99-4
Synonyms
  • AT-9311
  • LCQ-195
Molecular Formula
C17H19Cl2N5O4S
Formula Weight
460.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(NC1CCN(S(C)(=O)=O)CC1)C2=NNC=C2NC(C3=C(Cl)C=CC=C3Cl)=O
InChi Code
InChI=1S/C17H19Cl2N5O4S/c1-29(27,28)24-7-5-10(6-8-24)21-17(26)15-13(9-20-23-15)22-16(25)14-11(18)3-2-4-12(14)19/h2-4,9-10H,5-8H2,1H3,(H,20,23)(H,21,26)(H,22,25)
InChi Key
CCUXEBOOTMDSAM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    Product Description

    NVP-LCQ195 is an inhibitor of cyclin-dependent kinases (CDKs).1 It selectively inhibits Cdk5/p25, Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin A, and Cdk2/cyclin E complexes (IC50s = 1, 1, 2, 2, and 5 nM, respectively) over Cdk9/cyclin T1, Cdk3/cyclin E, Cdk6/cyclin D3, and Cdk7/cyclin H complexes (IC50s = 15, 42, 187, and 3,564 nM, respectively). NVP-LCQ195 decreases viability in a panel of 25 multiple myeloma cells (EC50s = 0.761-2.81 µM). It induces cell cycle arrest at the G0 phase and apoptosis in MM.1S multiple myeloma cells when used at a concentration of 2 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McMillin, D.W., Delmore, J., Negri, J., et al. Molecular and cellular effects of multi-targeted cyclin-dependent kinase inhibition in myeloma: Biological and clinical implications. Br. J. Haematol. 152(4), 420-432 (2011).