An FP receptor antagonist
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BAY-6672

Item No. 42731

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(+)-γ-[[[[6-bromo-3-methyl-2-(1-pyrrolidinyl)-4-quinolinyl]carbonyl]amino]methyl]-2-chloro-benzenebutanoic acid
CAS Number
2247517-53-7
Molecular Formula
C26H27BrClN3O3
Formula Weight
544.9
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1mg/mlDMSO: Slightly soluble: 0.1-1mg/ml
SMILES
CC1=C(C(NC[C@@H](C2=C(C=CC=C2)Cl)CCC(O)=O)=O)C3=C(C=CC(Br)=C3)N=C1N4CCCC4
InChi Code
InChI=1S/C26H27BrClN3O3/c1-16-24(20-14-18(27)9-10-22(20)30-25(16)31-12-4-5-13-31)26(34)29-15-17(8-11-23(32)33)19-6-2-3-7-21(19)28/h2-3,6-7,9-10,14,17H,4-5,8,11-13,15H2,1H3,(H,29,34)(H,32,33)/t17-/m0/s1
InChi Key
YQOLEILXOBUDMU-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $94

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    1 mg

    $179

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    5 mg

    $655

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    10 mg

    $1,029

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    Product Description

    BAY-6672 is an FP receptor antagonist (IC50 = 11 nM).1 It is selective for the FP receptor over the prostaglandin E2 (PGE2) receptor subtypes EP1, EP2, EP3, and EP4 (IC50s = >10, >10, >10, and >9.4 µM, respectively), as well as IP and DP receptors (IC50s = >10 µM for both). In vivo, BAY-6672 (30 mg/kg) reduces lung Il-1β levels and fibrosis in a mouse model of silica-induced pulmonary fibrosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beck, H., Thaler, T., Meibom, D., et al. Potent and selective human prostaglandin F (FP) receptor antagonist (BAY-6672) for the treatment of idiopathic pulmonary fibrosis (IPF). J. Med. Chem. 63(20), 11639-11662 (2020).