Active • Host: E. coli • AA: Met1; 54-206 • MW: 16.92 kDa
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FGF4 (human, recombinant)

Item No. 42758

Product Insert (PDF)
Technical Information
Synonyms
  • Fibroblast Growth Factor 4
  • HBGF-4
  • Heparin-binding Growth Factor 4
  • Heparin Secretory-Transforming Protein 1
  • HST-1
  • HSTF-1
  • K-FGF
  • Transforming Protein KS3
Purity
≥95% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg determined by the LAL endotoxin assay
Source
Active recombinant human FGF4 expressed in E. coli
Amino Acids
Met1; 54-206
MW
16.92 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4, 5% trehalose, 5% mannitol, and 0.01% Tween-80
UniProt Accession №
P08620
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    20 µg

    $178

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    100 µg

    $427

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    Product Description

    Fibroblast growth factor 4 (FGF4) is a secreted protein and member of the FGF4 subfamily and is involved in development.1 It is composed of an N-terminal signaling peptide, heparin-binding sites, and a receptor-binding domain.1,2 FGF4 is expressed in both epithelial and mesenchymal cells and, once secreted, binds to Ig-like domain IIIc on FGFR1, FGFR2, and FGFR3.3 FGF4 is required for embryonic development and is involved in limb and cardiac valve development, as well as the proliferation and differentiation of stem cells and many other processes.4,1,5 Cayman’s FGF4 (human, recombinant) protein can be used for cell-based assays. The protein was synthesized from a DNA sequence encoding the mature form of FGF4 (Ser54-Leu206) with an N-terminal translation-initiating methionine (Met1). The expressed protein consists of 154 amino acids, has a calculated molecular weight of 16.92 kDa, and a predicted N-terminus of Met1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ornitz, D.M., and Itoh, N. The Fibroblast Growth Factor signaling pathway. Wiley Interdiscip. Rev. Dev. Biol. 4(3), 215-266 (2015).

    2. Bellosta, P., Iwahori, A., Plotnikov, A.N., et al. Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. Mol. Cell. Biol. 21(17), 5946-5957 (2001).

    3. Ornitz, D.M., Xu, J., Colvin, J.S., et al. Receptor specificity of the fibroblast growth factor family. The Journal of Biological Chemisty 271(25), 15292-15297 (1996).

    4. Kosaka, N., Sakamoto, H., Terada, M., et al. Pleiotropic function of FGF-4: Its role in development and stem cells. Dev. Dyn. 238(2), 265-276 (2009).

    5. Sugi, Y., Ito, N., Szebenyi, G., et al. Fibroblast growth factor (FGF)-4 can induce proliferation of cardiac cushion mesenchymal cells during early valve leaflet formation. Dev. Biol. 258(2), 252-263 (2003).