Host: Insect cells • AA: 63-148 • MW: 9.7 kDa
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Soluble HB-EGF (human, recombinant)

Item No. 42767

Product Insert (PDF)
Technical Information
Synonyms
  • Diphtheria Toxin Receptor
  • DT-R
  • Heparin-binding EGF-like Growth Factor
  • Proheparin-binding EGF-like Growth Factor
Purity
≥95% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/g of the protein as determined by the LAL method
Source
Recombinant human soluble HB-EGF expressed in insect cells
Amino Acids
63-148
MW
9.7 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
UniProt Accession №
Q99075
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    10 µg

    $64

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    100 µg

    $383

    Add

    1 mg

    $2,552

    Add
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    Product Description

    Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family.1,2 It is expressed as a membrane-bound receptor that is composed of an N-terminal signal peptide, a propeptide sequence, a heparin-binding motif, an EGF fold, a linker region, a transmembrane region, and a C-terminal region.2 It can be proteolytically cleaved to release soluble HB-EGF composed of the heparin-binding motif and an EGF fold, which can bind and activate EGFR and HER4 receptors and activate HER2 receptors by inducing receptor heterodimerization.2,1 HB-EGF is involved in stimulating cell growth, wound healing, and heart development and maintenance and is a receptor for diphtheria toxin.3,1,2,4 Protein levels of HB-EGF are decreased in the placenta of patients with preeclampsia.5 Cayman's Soluble HB-EGF (human, recombinant) protein consists of 86 amino acids and has a calculated molecular weight of 9.7 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iwamoto, R., and Mekada, E. ErbB and HB-EGF signaling in heart development and function. Cell Struct. Funct. 31(1), 1-14 (2006).

    2. Louie, G.V., Yang, W., Bowman, M.E., et al. Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor. Mol. Cell 1(1), 67-78 (1997).

    3. Hashimoto, K., Higashiyama, S., Asada, H., et al. Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes. The Journal of Biological Chemisty 269(31), 20060-20066 (1994).

    4. Naglich, J.G., Metherall, J.E., Russell, D.W., et al. Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor. Cell 69(6), 1051-1061 (1992).

    5. Leach, R.E., Romero, R., Kim, Y.M., et al. Pre-eclampsia and expression of heparin-binding EGF-like growth factor. Lancet 360(9341), 1215-1219 (2002).