Host: HEK293 cells • AA: 17-220 • Tag: C-terminal His • MW: 25.3 kDa
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ANGPTL3 (human, recombinant)

Item No. 42772

Product Insert (PDF)
Technical Information
Synonyms
  • ANG-5
  • Angiopoietin-5
  • Angiopoietin-like 3
  • Angiopoietin-related Protein 3
Purity
≥95% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU per μg protein as determined by the LAL method.
Source
Recombinant human C-terminal His-tagged ANGPTL3 expressed in HEK293 cells
Amino Acids
17-220
MW
25.3 kDa
Storage Buffer
Lyophilized from sterile PBS, pH 7.4.
Host
HEK293 cells
UniProt Accession №
Q9Y5C1
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $270

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    1 mg

    $1,753

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    Cayman Chemical
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    Product Description

    Angiopoietin-like 3 (ANGPTL3) is an angiopoietin-related protein involved in lipid metabolism.1,2 It is composed of a signal peptide, coiled-coil domain, linker region, and C-terminal fibrinogen-like domain.2,3 ANGPTL3 is expressed in adult liver and during embryonic development.3 It inhibits the activity of lipoprotein lipase and endothelial lipase, which increases plasma triglycerides and HDL-cholesterol (HDL-C) levels.4,5,6 Loss-of-function mutations in ANGPTL3 are associated with decreased risk of coronary artery disease, coronary atherosclerosis, or myocardial infarction.6 Formulations containing monoclonal antibodies targeting ANGPTL3 have been used in the treatment of homozygous familial hypercholesterolemia. Cayman’s ANGPTL3 (human, recombinant) protein consists of 215 amino acids and has a calculated molecular weight of 25.3 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 36.9 kDa due to glycosylation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kadomatsu, T., Tabata, M., and Oike, Y. Angiopoietin-like proteins: Emerging targets for treatment of obesity and related metabolic diseases. FEBS J. 278(4), 559-564 (2011).

    2. Oike, Y., Akao, M., Kubota, Y., et al. Angiopoietin-like proteins: Potential new targets for metabolic syndrome therapy. Trends Mol. Med. 11(10), 473-479 (2005).

    3. Conklin, D., Gilbertson, D., Taft, D.W., et al. Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics 62(3), 477-482 (1999).

    4. Shan, L., Yu, X.C., Liu, Z., et al. The Angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms. The Journal of Biological Chemisty 284(3), 1419-1424 (2009).

    5. Shimamura, M., Matsuda, M., Yasumo, H., et al. Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Arterioscler. Thromb. Vasc. Biol. 27(2), 366-372 (2007).

    6. Luo, F., Das, A., Khetarpal, S.A., et al. ANGPTL3 inhibition, dyslipidemia, and cardiovascular diseases. Trends Cardiovasc. Med. 34(4), 215-222 (2024).