For immunochemical detection of FGL1
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

FGL1 Rabbit Monoclonal Antibody (Clone RM502)

Item No. 42775

Product Insert (PDF)
Technical Information
Synonyms
  • Fibrinogen-like Protein 1
  • Hepassocin
  • Hepatocyte-derived Fibrinogen-related Protein 1
  • HFREP-1
  • HP-041
  • HPS
  • Liver Fibrinogen-related Protein
  • LFIRE-1
Immunogen
Peptide corresponding to the C-terminus of human FGL1
Clone Designation
RM502
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) FGL1
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Fibrinogen-like protein 1 (FGL1) is a member of the fibrinogen protein family.1,2 It functions as a homodimer and is composed of an N-terminal coiled-coiled domain, which promotes homo-oligomerization or hetero-oligomerization with lymphocyte activation gene 3 (LAG-3), and a C-terminal fibrinogen-like domain but lacks a platelet-binding region found in other fibrinogen proteins.1 FGL1 is expressed in and secreted from the liver and to a lesser extent in brown adipose tissue.1,3 It decreases anti-Cd3-induced proliferation in wild-type mouse T cells but not in Lag3-/- mouse T cells.2 Fgl1 knockout increases body weight, the liver weight to body weight ratio, hepatic triglyceride levels, and plasma cholesterol, free fatty acid, and glucose levels in mice.3 Plasma FGL1 levels are increased in patients with hyperglycemia.4 Cayman's FGL1 Rabbit Monoclonal Antibody (Clone RM502) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamamoto, T., Gotoh, M., Sasaki, H., et al. Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. Biochem. Biophys. Res. Commun. 193(2), 681-687 (1993).

    2. Wang, J., Sanmamed, M.F., Datar, I., et al. Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3. Cell 176(1-2), 334-347.e312 (2019).

    3. Demchev, V., Malana, G., Vangala, D., et al. Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization. PLos One 8(3), e58084 (2013).

    4. Ou, H.-Y., Wu, H.-T., Lin, C.-H., et al. The hepatic protection effects of hepassocin in hyperglycemic crisis. J. Clin. Endocrinol. Metab. 102(7), 2407-2415 (2017).