For immunochemical detection of PTEN
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PTEN Rabbit Monoclonal Antibody (Clone RM511)

Item No. 42778

Product Insert (PDF)
Technical Information
Synonyms
  • MMAC1
  • Mutated in Multiple Advanced Cancers 1
  • Phosphatase and Tensin Homolog
  • TEP1
Immunogen
A peptide corresponding to residues at the C-terminus of human PTEN
Clone Designation
RM511
Formulation (Request formulation change)
100 µg of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC
Cross Reactivity
(+) PTEN
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    Phosphatase and tensin homolog (PTEN) is a tumor suppressor with roles in cell division, cell migration, and apoptosis.1,2,3,4 It is ubiquitously expressed and localized to the cytosol and nucleus where it dephosphorylates phosphatidylinositol-(3,4,5)-triphosphate (PIP3) to phosphatidylinositol-(3,4)-diphosphate (PIP2) to antagonize PI3K signaling and regulates spliceosome assembly and pre-mRNA splicing, respectively.2 PTEN inhibits cell cycle progression and induces apoptosis, as well as inhibits cell adhesion and migration in vitro.5 PTEN deletions have been found in various cancers, including glioblastomas and prostate, breast, and kidney cells. Germline mutations in PTEN induce a variety of syndromes, including Cowden, Bannayan-Riley-Ruvalcaba, Proteus, and Proteus-like syndromes, which are characterized by increased risk of cancers, developmental delays, autism spectrum disorders, and macroencephaly.4 Cayman’s PTEN Rabbit Monoclonal Antibody (Clone RM511) can be used for immunohistochemistry (IHC).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Di Cristofano, A., and Pandolfi, P.P. The multiple roles of PTEN in tumor suppression. Cell 100(4), 387-390 (2000).

    2. Liang, H., and Yin, Y. Multiple roles of PTEN isoforms PTENα and PTENβ in cellular activities and tumor development. Sci. China Life Sci. 62(12), 1722-1724 (2019).

    3. Boossani, C.S., Gunasekar, P., and Agrawal, D.K. An update on PTEN modulators - a patent review. Expert Opin. Ther. Pat. 29(11), 881-889 (2019).

    4. Nunes-Santos, C.J., Uzel, G., and Rosenzweig, S.D. PI3K pathway defects leading to immunodeficiency and immune dysregulation. J. Allergy Clin. Immunol. 143(5), 1676-1687 (2019).

    5. Dahia, P.L.M. PTEN, a unique tumor suppressor gene. Endocr. Relat. Cancer 7(2), 115-129 (2000).