For immunochemical detection of H2BK11Ac
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Histone H2BK11Ac Rabbit Monoclonal Antibody (Clone RM456)

Item No. 42791

Product Insert (PDF)
Technical Information
Synonyms
  • Acetylated Histone H2B Lysine 11
Immunogen
An acetyl-peptide corresponding to Acetyl-Histone H2B (Lys11)
Clone Designation
RM456
Formulation (Request formulation change)
100 µg of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ELISA, multiplex-based assay, WB
Cross Reactivity
(+) H2BK11Ac(-) Unmodified H2BK11(-) H2B5Ac(-) H2BK12Ac(-) H2BK15Ac(-) H2BK16Ac(-) H2BK20Ac
Species Reactivity
(+) Human(+) Vertebrates
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $500

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    Product Description

    Histone H2B is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.1 It is a globular protein that contains a histone fold domain with a C-terminal α-helix that facilitates nucleosome interactions and chromatin compaction, as well as an unstructured N-terminal tail that extends outside of the nucleosome core, both of which are subject to various post-translational modifications (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation.1,2,3 Acetylation of histone H2B at lysine 11 (H2BK11Ac) is downregulated in a mouse model of allergic asthma.4 Cayman's Histone H2BK11Ac Rabbit Monoclonal Antibody (Clone RM456) can be used for ELISA, multiplex-based assay, and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hyun, K., Jeon, J., Park, K., et al. Writing, erasing and reading histone lysine methylations. Exp. Mol. Med. 49(4), e324 (2017).

    2. Wyrick, J.J., and Parra, M.A. The role of histone H2A and H2B post-translational modifications in transcription: A genomic perspective. Biochim. Biophys. Acta 1789(1), 37-44 (2009).

    3. Wang, C.-Y., Hua, C.-Y., Hsu, H.-E., et al. The C-terminus of histone H2B is involved in chromatin compaction specifically at telomeres, independently of its monoubiquitylation at lysine 123. PLoS One 6(7), e22209 (2011).

    4. Ren, Y., Li, M., Bai, S., et al. Identification of histone acetylation in a murine model of allergic asthma by proteomic analysis. Exp. Biol. Med. (Maywood) 246(8), 929-939 (2021).