HPH-15

HPH-15 is an antifibrotic compound and AMPK activator.^1,2 It inhibits TGF-β1-induced collagen, fibronectin 1, and connective tissue growth factor (CTGF) production in primary human dermal fibroblasts when used at a concentration of 3 µM.¹ HPH-15 (10 µM) increases AMPK activation, glucose uptake, and membrane translocation of glucose transporter 4 (Glut4) in L6 rat myocytes expressing the human transporter.² It inhibits glucose-induced triglyceride production in HepG2 cells when used at a concentration of 50 µM. In vivo, HPH-15 (10 mg/kg) reduces blood glucose levels, increases AMPK activation, and suppresses hepatic fibrosis and lipid accumulation in mice fed a high-fat diet. It also decreases dermal thickness and inflammatory cell infiltration in a mouse model of fibrosis induced by bleomycin (Item No. 13877).¹

WARNING This product is not for human or veterinary use.

1. Luong, V.H., Chino, T., Oyama, N., et al. Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis. Arthritis Res. Ther. 20(1), 46 (2018).

2. Toma, T., Miyakawa, N., Arakaki, Y., et al. An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models. Diabetologia 67(11), 2568-2584 (2024).