For immunochemical detection of MUC1
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MUC1 Rabbit Monoclonal Antibody (Clone RM489)

Item No. 42843

Product Insert (PDF)
Technical Information
Synonyms
  • BM7
  • Breast Carcinoma-associated Antigen DF3
  • CA 15-3
  • Cancer Antigen 15-3
  • Mucin 1
  • PEM
  • Polymorphic Epithelial Mucin
  • KL-6
Immunogen
Peptide corresponding to the cytoplasmic domain of human MUC1
Clone Designation
RM489
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) MUC1
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Product Description

    Mucin 1 (MUC1) is a member of the mucin family.1 It is expressed as a proprotein that is cleaved into extracellular and transmembrane polypeptides.1,2 The extracellular polypeptide is composed of a tandem repeat domain, which contains O- and N-linked glycosylation sites, and is attached non-covalently to the transmembrane polypeptide, which is composed of a juxtamembrane region, a transmembrane domain, and a C-terminal cytoplasmic tail.1 MUC1 is ubiquitously expressed in tissues, such as stomach peptic cells, organ endothelium and epithelium, and liver bile ducts, and functions as an extracellular barrier, serves as an anchor for intercellular proteins, such as intercellular adhesion molecule-1 (ICAM-1), or associates with other receptors, such as EGFR, to assist in signal transduction.2 MUC1 can undergo alternative splicing to produce secreted or intracellular MUC1 isoforms.3 In tumors, MUC1 prevents immune cell recognition and engagement, increases metastatic potential, and is frequently overexpressed in cancers.3 Serum and tumor levels of MUC1 are increased in patients with breast cancer.4 Cayman's MUC1 Rabbit Monoclonal Antibody (Clone RM489) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Horm, T.M., and Schroeder, J.A. MUC1 and metastatic cancer: Expression, function and therapeutic targeting. Cell. Adh. Migr. 7(2), 187-198 (2013).

    2. Hanisch, F.G., and Müller, S. MUC1: The polymorphic appearance of a human mucin. Glycobiology 10(5), 439-449 (2000).

    3. Brockhausen, I., and Melamed, J. Mucins as anti-cancer targets: Perspectives of the glycobiologist. Glycoconj. J. 38(4), 459-474 (2021).

    4. Croce, M.V., Isla-Larrain, M.T., Demichelis, S.O., et al. Tissue and serum MUC1 mucin detection in breast cancer patients. Breast Cancer Res. Treat. 81(3), 195-207 (2003).