An acetylated derivative of L-leucine
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

N-acetyl-L-Leucine

Item No. 42889

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
1188-21-2
Synonyms
  • Levacetylleucine
  • NALL
  • NSC 206316
Molecular Formula
C8H15NO3
Formula Weight
173.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (7.2 pH): Sparingly soluble: 1-10 mg/ml
SMILES
CC(C)C[C@H](NC(C)=O)C(O)=O
InChi Code
InChI=1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1
InChi Key
WXNXCEHXYPACJF-ZETCQYMHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 g

    $50

    Add

    25 g

    $118

    Add
    Product Description

    N-acetyl-L-Leucine is an acetylated derivative of the essential amino acid L-leucine (Item No. 34342).1 It decreases lesion size and improves sensorimotor deficits in the beam walk test in a mouse model of controlled cortical impact-induced traumatic brain injury (TBI) when administered at a dose of 100 mg/kg per day. N-acetyl-L-Leucine (100 mg/kg per day) increases the latency to fall from the rotarod, increases substantia nigra levels of tyrosine hydroxylase, and decreases serum levels of Il-6 in a mouse model of MPTP-induced Parkinson's disease.2 Formulations containing N-acetyl-L-leucine have been used in the treatment of Niemann-Pick disease type C.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hegdekar, N., Lipinski, M.M., and Sarkar, C. N-Acetyl-L-leucine improves functional recovery and attenuates cortical cell death and neuroinflammation after traumatic brain injury in mice. Sci. Rep. 11(1), 9249 (2021).

    2. Xu, Z., Lian, C., Pan, L., et al. N-acetyl-L-leucine protects MPTP-treated Parkinson’s disease mouse models by suppressing Desulfobacterota via the gut-brain axis. Brain Res. Bull. 202, 110729 (2023).