An essential amino acid
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L-Leucine

Item No. 34342

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
61-90-5
Synonyms
  • Leu
  • NSC 46709
Molecular Formula
C6H13NO2
Formula Weight
131.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
SMILES
CC(C)C[C@H](N)C(O)=O
InChi Code
InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChi Key
ROHFNLRQFUQHCH-YFKPBYRVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 g

    $36

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    100 g

    $68

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    500 g

    $219

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    L-Leucine is an essential amino acid.1 It increases basal insulin secretion and decreases glucose-induced insulin release in INS-1E rat insulinoma cells when used at concentrations of 1, 5, and 10 mM.2 L-Leucine (1, 5, and 10 mM) decreases triglyceride levels and increases cholesterol accumulation in INS-1E cells. It stimulates skeletal muscle protein synthesis in exercised rats, as well as in food-deprived rats in an mTOR-dependent manner.3,4 Formulations containing L-leucine have been used as dietary supplements.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Duan, Y., Li, F., Li, Y., et al. The role of leucine and its metabolites in protein and energy metabolism. Amino Acids 48(1), 41-51 (2016).

    2. Liu, Z., Jeppesen, P.B., Gregersen, S., et al. Chronic exposure to leucine in vitro induces β-cell dysfunction in INS-1E cells and mouse islets. J. Endocrinol. 215(1), 79-88 (2012).

    3. Anthony, J.C., Yoshizawa, F., Anthony, T.G., et al. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J. Nutr. 130(10), 2413-2419 (2000).

    4. Anthony, J.C., Anthony, T.G., and Layman, D.K. Leucine supplementation enhances skeletal muscle recovery in rats following exercise. J. Nutr. 129(6), 1102-1106 (1999).