A polyfluoroalkyl substance
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9-Chlorohexadecafluoro-3-oxanonane-1-sulfonate (potassium salt)

Item No. 42909

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(6-chloro-1,1,2,2,3,3,4,4,5,5,6,6-dodecafluorohexyl)oxy]-1,1,2,2-tetrafluoro-ethanesulfonic acid, monopotassium salt
CAS Number
73606-19-6
Synonyms
  • C8 Cl-PFESA
  • 6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate
  • 6:2 Chlorinated Polyfluoroalkyl Ether Sulfonic Acid
  • 6:2 Cl-PFAES
  • 6:2 Cl-PFESA
  • 9Cl-PF3ONS
Molecular Formula
C8ClF16O4S • K
Formula Weight
570.7
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=S([O-])(C(F)(C(F)(OC(F)(C(F)(C(F)(C(F)(C(F)(C(F)(Cl)F)F)F)F)F)F)F)F)=O.[K+]
InChi Code
InChI=1S/C8HClF16O4S.K/c9-5(18,19)3(14,15)1(10,11)2(12,13)4(16,17)6(20,21)29-7(22,23)8(24,25)30(26,27)28;/h(H,26,27,28);/q;+1/p-1
InChi Key
OWQCHLFKOGVODW-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    9-Chlorohexadecafluoro-3-oxanonane-1-sulfonate (9Cl-PF3ONS) is a chlorinated polyfluoroalkyl substance (PFAS).1 It binds to the ligand-binding domains of estrogen receptor α (ERα) and ERβ (IC50s = 99.3 and 63.4 µM, respectively, for the human receptors) and increases the levels of vitellogenin (Vtg), estradiol (E2), and testosterone in zebrafish larvae when used at a concentration of 500 nM. 9Cl-PF3ONS (20 and 100 mg/kg) decreases serum triiodothyronine (T3) and thyroxine (T4) levels and induces thyroid gland follicular hyperplasia in rats.2 It has been found in breast milk and negatively correlates with infant length gain rate.3 9Cl-PF3ONS has also been found in river and lake water.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xin, Y., Wan, B., Yu, B., et al. Chlorinated polyfluoroalkylether sulfonic acids exhibit stronger estrogenic effects than perfluorooctane sulfonate by activating nuclear estrogen receptor pathways. Environ. Sci. Technol. 54(6), 3455-3464 (2020).

    2. Hong, S.-H., Lee, S.H., Yang, J.-Y., et al. Orally administered 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) causes thyroid dysfunction in rats. Toxics 8(3), 54 (2020).

    3. Jin, H., Mao, L., Xie, J., et al. Poly- and perfluoroalkyl substance concentrations in human breast milk and their associations with postnatal infant growth. Sci. Total Environ. 713, 136417 (2020).

    4. Wang, Y., Shi, Y., and Cai, Y. Spatial distribution, seasonal variation and risks of legacy and emerging per- and polyfluoroalkyl substances in urban surface water in Beijing, China. Sci. Total Environ. 673, 177-183 (2019).