An allosteric inhibitor of LIMK1 and LIMK2
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MDI-114215

Item No. 42919

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(cyclopropylmethyl)-N-(4-((2-hydroxyethyl)amino)benzyl)-4-(N-phenylsulfamoyl)benzamide
Molecular Formula
C26H29N3O4S
Formula Weight
479.6
Purity
≥97%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
O=S(NC1=CC=CC=C1)(C2=CC=C(C(N(CC3CC3)CC4=CC=C(NCCO)C=C4)=O)C=C2)=O
InChi Code
InChI=1S/C26H29N3O4S/c30-17-16-27-23-12-8-21(9-13-23)19-29(18-20-6-7-20)26(31)22-10-14-25(15-11-22)34(32,33)28-24-4-2-1-3-5-24/h1-5,8-15,20,27-28,30H,6-7,16-19H2
InChi Key
RXSCURXNWIHEAV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $330

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    Product Description

    MDI-114215 is an allosteric inhibitor of LIM kinase 1 (LIMK1) and LIMK2 (IC50s = 19.95 and 26.92 nM, respectively).1 It is selective for LIMK1 and LIMK2 in a panel of 468 kinases but does bind to cyclin-dependent kinase 7 (Cdk7), MAP kinase kinase 7 (MKK7), vaccinia-related kinase 2 (VRK2), and phosphorylated Abl1 at 300 nM. MDI-114215 is also selective for LIMK1 and LIMK2 in a panel of 44 receptors, ion channels, transporters, and enzymes but does bind to cannabinoid 1 (CB1) receptor at 10 µM. It reduces the levels of cofilin phosphorylated by p21-activated kinase 1 (PAK1) in SH-SY5Y cells (IC50 = 50.12 nM). MDI-114215 (3 µM) enhances long-term potentiation (LTP) in hippocampal slices from Fmr1 knockout mice, which lack the gene encoding fragile X mental retardation 1 protein (FMRP).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baldwin, A.G., Foley, D.W., Collins, R., et al. Discovery of MDI-114215: A potent and selective LIMK inhibitor to treat Fragile X Syndrome. J. Med. Chem. 68(1), 719-752 (2025).