A synthetic intermediate of tadalafil
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Chloropretadalafil

Item No. 42945

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,3R)-1-(1,3-benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid, methyl ester
CAS Number
171489-59-1
Molecular Formula
C22H19ClN2O5
Formula Weight
426.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C([C@@H](CC1=C2NC3=CC=CC=C31)N(C(CCl)=O)[C@@H]2C4=CC=C5OCOC5=C4)OC
InChi Code
InChI=1S/C22H19ClN2O5/c1-28-22(27)16-9-14-13-4-2-3-5-15(13)24-20(14)21(25(16)19(26)10-23)12-6-7-17-18(8-12)30-11-29-17/h2-8,16,21,24H,9-11H2,1H3/t16-,21-/m1/s1
InChi Key
JUKHNCNDFOAFLT-IIBYNOLFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

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    Product Description

    Chloropretadalafil is an intermediate in the synthesis of the phosphodiesterase 5 (PDE5) inhibitor tadalafil (Item No. 14024).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Daugan, A., Grondin, P., Ruault, C., et al. The discovery of tadalafil: A novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. J. Med. Chem. 46(21), 4533-4542 (2003).