A TXNIP inhibitor
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SKL1223

Item No. 42952

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(furan-2-ylmethyl)-4-(3-phenyl-1,2,4-oxadiazol-5-yl)aniline
Molecular Formula
C19H15N3O2
Formula Weight
317.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
C1(NCC2=CC=CO2)=CC=C(C3=NC(C4=CC=CC=C4)=NO3)C=C1
InChi Code
InChI=1S/C19H15N3O2/c1-2-5-14(6-3-1)18-21-19(24-22-18)15-8-10-16(11-9-15)20-13-17-7-4-12-23-17/h1-12,20H,13H2
InChi Key
PWITXLYJAFNARC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $175

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    10 mg

    $297

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    SKL1223 is an inhibitor of thioredoxin-interacting protein (TXNIP).1 It inhibits TXNIP promoter activity in a reporter assay using INS-1 cells expressing human TXNIP (IC50 = 0.64 µM) and decreases the levels of TXNIP in the same cells in a concentration-dependent manner. SKL1223 (5 or 20 µM) induces glucagon secretion from TC-1 mouse lung cancer cells and decreases glucagon-induced glucose production in primary mouse hepatocytes. It decreases fasting blood levels of glucose, serum levels of glucagon and triglycerides, and hepatic levels of triglycerides in mice when administered at a dose of 70 mg/kg per day. SKL1223 decreases blood levels of glucose and serum levels of glucagon in db/db mice but not in Txnip-/- mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, X., Luo, Z., Han, J., et al. Orally available small molecule regulates TXNIP expression and glucagon action for the treatment of diabetes. Research Square (2024).