A SRPK1 inhibitor
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SPHINX

Item No. 42958

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-methyl-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-2-furancarboxamide
CAS Number
848057-98-7
Molecular Formula
C17H17F3N2O3
Formula Weight
354.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CC1=CC=C(O1)C(NC2=CC(C(F)(F)F)=CC=C2N3CCOCC3)=O
InChi Code
InChI=1S/C17H17F3N2O3/c1-11-2-5-15(25-11)16(23)21-13-10-12(17(18,19)20)3-4-14(13)22-6-8-24-9-7-22/h2-5,10H,6-9H2,1H3,(H,21,23)
InChi Key
FZCPNRVICXFZJR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $147

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    10 mg

    $230

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    25 mg

    $367

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    Product Description

    SPHINX is an inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 0.88 µM).1 It is selective for SRPK1 over SRPK2 (IC50 = >10 µM). SPHINX (10 µM) inhibits EGF-induced increases in phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1) in ARPE-19 retinal epithelial cells. It decreases lesion area and choroidal neovascularization in mouse eyes in a model of laser-induced photocoagulation when administered at a dose of 25 ng/eye. SPHINX reduces tumor growth in a PC3 prostate cancer mouse xenograft model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gammons, M.V., Fedorov, O., Ivison, D., et al. Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD. Invest. Ophthalmol. Vis. Sci. 54(9), 6052-6062 (2013).

    2. Mavrou, A., Brakspear, K., Hamdollah-Zadeh, M., et al. Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer. Oncogene 34(33), 4311-4319 (2015).