A synthetic estrogen
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3-O-methyl Estradiol

Item No. 42995

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(17β)-3-methoxy-estra-1,3,5(10)-trien-17-ol
CAS Number
1035-77-4
Synonyms
  • Estradiol 3-methyl ether
  • 3-Methoxyestradiol
  • 3-O-methyl E2
  • NSC 58851
Molecular Formula
C19H26O2
Formula Weight
286.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(OC)C=C4CC3
InChi Code
InChI=1S/C19H26O2/c1-19-10-9-15-14-6-4-13(21-2)11-12(14)3-5-16(15)17(19)7-8-18(19)20/h4,6,11,15-18,20H,3,5,7-10H2,1-2H3/t15-,16-,17+,18+,19+/m1/s1
InChi Key
ULAADVBNYHGIBP-GFEQUFNTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    3-O-methyl Estradiol is a synthetic estrogen.1 It disrupts microtubule networks in V79 Chinese hamster cells (EC50 = 9 µM) and inhibits the proliferation of the same cells by 92% when used at a concentration of 20 µM. 3-O-methyl Estradiol (25 mg in a 0.2 ml solution, p.o.) decreases serum cholesterol levels and increases body weight loss, indicating feminizing activity, in male rats fed a high-cholesterol diet.2 It has been used as a standard for the quantification of 17β-estradiol in hen urine.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aizu-Yokota, E., Susaki, A., and Sato, Y. Natural estrogens induce modulation of microtubules in Chinese hamster V79 cells in culture. Cancer Res. 55(9), 1863-1868 (1995).

    2. Tomarelli, R.M., Dougherty, T.M., and Bernhart, F.W. Bioassay of hypocholesterolemic steroids. J. Pharm. Sci. 55(12), 1392-1395 (1966).

    3. Hertelendy, F., Taylor, T.G., Mathur, R.S., et al. Isolation of estradiol-17β from hen’s urine and its characterization as the crystalline 3-methyl ether. Can. J. Biochem. 43(9), 1379-1385 (1965).