A GC-A antagonist
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A71915 (trifluoroacetate salt)

Item No. 43005

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-cysteinyl-3-cyclohexyl-L-alanylglycylglycyl-L-arginyl-L-isoleucyl-L-α-aspartyl-L-arginyl-L-isoleucyl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-arginyl-L-cysteinamide, cyclic (2→13)-disulfide, trifluoroacetate salt
Synonyms
  • [Arg6,Cha8]ANP-(6-15)-D-Tic-Arg-Cys-NH2
  • [Arg6,Cha8]Atrial Natriuretic Peptide-(6-15)-D-Tic-Arg-Cys-NH2
Molecular Formula
C69H116N26O15S2 • XCF3COOH
Formula Weight
1614.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
Cyclo(RCX1GGRIDRIX2RC)-NH2 (X1 = Cyclohexylalanine; X2 = D-1,2,3,4-Tetrahydro-3-isoquinolinecar
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (7.2 pH): Sparingly soluble: 1-10 mg/ml
SMILES
O=C1N2[C@](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@@]1([H])[C@@H](C)CC)=O)CCCNC(N)=N)=O)CC(O)=O)=O)([H])[C@@H](C)CC)=O)CCCNC(N)=N)=O)=O)=O)CC3CCCCC3)=O)NC([C@@H](N)CCCNC(N)=N)=O)C(N)=O)=O)CCCNC(N)=N)=O)([H])CC4=CC=CC=C4C2.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C69H116N26O15S2.C2HF3O2/c1-5-36(3)53-64(109)90-46(30-52(98)99)61(106)87-44(23-15-27-83-69(78)79)60(105)94-54(37(4)6-2)65(110)95-33-40-19-11-10-18-39(40)29-49(95)63(108)88-43(22-14-26-82-68(76)77)58(103)91-47(55(71)100)34-111-112-35-48(92-56(101)41(70)20-12-24-80-66(72)73)62(107)89-45(28-38-16-8-7-9-17-38)57(102)85-31-50(96)84-32-51(97)86-42(59(104)93-53)21-13-25-81-67(74)75;3-2(4,5)1(6)7/h10-11,18-19,36-38,41-49,53-54H,5-9,12-17,20-35,70H2,1-4H3,(H2,71,100)(H,84,96)(H,85,102)(H,86,97)(H,87,106)(H,88,108)(H,89,107)(H,90,109)(H,91,103)(H,92,101)(H,93,104)(H,94,105)(H,98,99)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)(H4,78,79,83);(H,6,7)/t36-,37-,41-,42-,43-,44-,45-,46-,47-,48-,49+,53-,54-;/m0./s1
InChi Key
MVTYOEJNLDZOOR-FVZXGZEGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $327

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    10 mg

    $491

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    25 mg

    $1,089

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    Product Description

    A71915 is an antagonist of guanylyl cyclase A receptor (GC-A; Ki = 0.66 nM).1 It inhibits cGMP production induced by atrial natriuretic peptide (ANP) in NB-OK-1 cells (pA2 = 9.48). A71915 (1 µM) induces dilation and increases glomerular blood flow in rat hydronephrotic renal vascular segments but inhibits ANP-induced dilation in the same preparations.2 It also prevents increases in spontaneous action potential frequency induced by brain natriuretic peptide (BNP) in isolated mouse sinoatrial node myocytes when used at a concentration of 0.5 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Delporte, C., Winand, J., Poloczek, P., et al. Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur. J. Pharmacol. 224(2-3), 183-188 (1992).

    2. Endlich, K., and Steinhausen, M. Natriuretic peptide receptors mediate different responses in rat renal microvessels. Kidney Int. 52(1), 202-207 (1997).

    3. Springer, J., Azer, J., Hua, R., et al. The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors. J. Mol. Cell. Cardiol. 52(5), 1122-1134 (2012).