A peptide inhibitor of PKC
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[Ala107]-Myelin Basic Protein (104-118) (acetate)

Item No. 43009

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-2-((5S,11S,14S,17S,20S,23S,26S,29S,32S,38S)-32-((1H-indol-3-yl)methyl)-26-benzyl-23-(3-((diaminomethylene)amino)propyl)-38-(hydroxyamino)-14,20,29-tris(hydroxymethyl)-11,17-diisobutyl-5-methyl-4,7,10,13,16,19,24,25,28,31,34,37-dodecaoxo-3,6,9,12,15,18,21,22,27,30,33,36-dodecaazanonatriacontanamido)-6-amino-N-(2-oxoethyl)hexanamide, acetate
Synonyms
  • [Ala107]-MBP (104-118)
Molecular Formula
C67H104N20O19 • XC2H4O2
Formula Weight
1493.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
GKGAGLSLSRFSWGA-OH
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(N[C@@H](CCCCN[H])C(NCC(N[C@H](C(NCC(N[C@H](C(N[C@@H](CO[H])C(N[C@H](C(N[C@@H](CO[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CO[H])C(N[C@@H](CC1=CN([H])C2=C1C=CC=C2)C(NCC(N[C@H](C(O)=O)C)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)C)=O)=O)CN[H].CC(O)=O
InChi Code
InChI=1S/C67H104N20O19.C2H4O2/c1-35(2)23-45(80-55(94)31-74-56(95)37(5)77-53(92)29-75-57(96)43(19-12-13-21-68)79-52(91)27-69)60(99)85-50(33-89)64(103)82-46(24-36(3)4)61(100)86-49(32-88)63(102)81-44(20-14-22-72-67(70)71)59(98)83-47(25-39-15-8-7-9-16-39)62(101)87-51(34-90)65(104)84-48(26-40-28-73-42-18-11-10-17-41(40)42)58(97)76-30-54(93)78-38(6)66(105)106;1-2(3)4/h7-11,15-18,28,35-38,43-51,73,88-90H,12-14,19-27,29-34,68-69H2,1-6H3,(H,74,95)(H,75,96)(H,76,97)(H,77,92)(H,78,93)(H,79,91)(H,80,94)(H,81,102)(H,82,103)(H,83,98)(H,84,104)(H,85,99)(H,86,100)(H,87,101)(H,105,106)(H4,70,71,72);1H3,(H,3,4)/t37-,38-,43-,44-,45-,46-,47-,48-,49-,50-,51-;/m0./s1
InChi Key
KYNYLKQAKFESAQ-QDZOGIIMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    [Ala107]-Myelin basic protein (MBP) (104-118) is a peptide inhibitor of PKC.1 It is selective for PKC over myosin light-chain kinase (MLCK) and PKA at 100 µM. [Ala107]-MBP (104-118) inhibits the phosphorylation of histone H1, MBP, [Ala105]-MBP (104-118), MBP (104-118), and MBP (104-123) by PKC with IC50 values of 126, 145, 46, 72, and 63 µM, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Su, H.D., Kemp, B.E., Turner, R.S., et al. Synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase C). Biochem. Biophys. Res. Commun. 134(1), 78-84 (1986).