A PI4KIIIβ inhibitor
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UCB 9608

Item No. 43027

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S)-4-(6-amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methyl-1-piperazinecarboxamide
CAS Number
1616413-96-7
Molecular Formula
C20H26N8O2
Formula Weight
410.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CN1C2=NC(N)=NC(N3CCN(C[C@@H]3C)C(NC4=CC=C(C=C4C)OC)=O)=C2C=N1
InChi Code
InChI=1S/C20H26N8O2/c1-12-9-14(30-4)5-6-16(12)23-20(29)27-7-8-28(13(2)11-27)18-15-10-22-26(3)17(15)24-19(21)25-18/h5-6,9-10,13H,7-8,11H2,1-4H3,(H,23,29)(H2,21,24,25)/t13-/m0/s1
InChi Key
WRONAJQPZWDYAR-ZDUSSCGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    UCB 9608 is an inhibitor of PI4KIIIβ (IC50 = 11 nM). It is selective for PI4KIIIβ over 8 other phosphatidylinositol kinases at 10 µM.1 UCB 9608 inhibits the mixed lymphocyte reaction in isolated human peripheral blood mononuclear cells (PBMCs; IC50 = 37 nM). It increases heart allograft survival in mice when administered at a dose of 5 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reuberson, J., Horsley, H., Franklin, R.J., et al. Discovery of a potent, orally bioavailable PI4KIIIβ inhibitor (UCB9608) able to significantly prolong allogeneic organ engraftment in vivo. J. Med. Chem. 61(15), 6705-6723 (2018).